Publication
Title
The incidence and time path of lymphedema in sentinel negative breast cancer patients : a systematic review
Author
Abstract
Objective To systematically assess the incidence/prevalence and time path of lymphedema in sentinel node negative breast cancer patients. Data sources A systematic literature search was performed using four different electronic databases (Pubmed, Embase, Cochrane Clinical Trials, WoS) until November 2013. Study selection Inclusion criteria were: 1) research studies that included breast cancer patients who were surgically treated using the sentinel lymph node technique (SLNB), 2) sentinel node negative patients, 3) studies that investigated lymphedema as a primary or secondary outcome, 4) data extraction for incidence or time path of lymphedema was possible and 5) publication date starting from 1st January 2001. Exclusion criteria were (1) reviews or case studies, (2) patients who have had a SLNB followed by an axillary lymph node dissection (ALND), (3) results of ALND-patients and SLNB-patients were not described separately and (4) studies not written in English . Data extraction after scoring the methodological quality of the selected studies, the crude data concerning the incidence of lymphedema were extracted. Data concerning the time points and the incidence of lymphedema were also extracted. Data synthesis 28 articles were included, representing 9,588 SLNB negative patients. The overall incidence of lymphedema in sentinel node negative breast cancer patients ranged from 0% to 63.4%. The studies that have assessed lymphedema at predefined time points, instead of a mean follow-up time, demonstrated an incidence range at ≤3, 6, 12, 18 or > 18 months post-surgery of 3.2-5%, 2-10%, 3-63.4%, 6.6-7% and 6.9-8.2% respectively. Conclusion In SLNB-patients there is still a problem of lymphedema, if so it mostly occurs 6 to 12 months after surgery. Due to different assessments and criteria there is a wide range in incidence. Clear definitions of lymphedema are absolutely necessary to tailor therapy.
Language
English
Source (journal)
Archives of physical medicine and rehabilitation. - Chicago, Ill., 1952, currens
Publication
Chicago, Ill. : 2015
ISSN
0003-9993
Volume/pages
96:6(2015), p. 1131-1139
ISI
000356398200022
Full text (Publisher's DOI)
Full text (open access)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 06.02.2015
Last edited 31.08.2017
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