Title
Monoclonal antibodies for the treatment of non-haematological tumours : update of an expanding scenario Monoclonal antibodies for the treatment of non-haematological tumours : update of an expanding scenario
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
London :Informa healthcare ,
Subject
Biology
Human medicine
Engineering sciences. Technology
Source (journal)
Expert opinion on biological therapy
Volume/pages
15(2015) :1 , p. 45-59
ISSN
1471-2598
ISI
000346080900006
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Introduction: The identification of cell membrane-bound molecules with a relevant role in cancer cell survival prompted the development of moAbs to block the related pathways. In the last few years, the number of approved moAbs for cancer treatment has constantly increased. Many of these drugs significantly improved the survival outcomes in patients with solid tumours. Areas covered: In this review, all the FDA-approved moAbs in solid tumours have been described. This is an update of moAbs available for cancer treatment nowadays in comparison with the moAbs approved until few years ago. The moAbs under development are also discussed here. Expert opinion: The research on cancer antigens as therapeutic targets led to an expanding scenario of available treatment options in non-haematological malignancies. In a few years, the number of approved drugs has increased rapidly. Some of these agents are actually on label in combination with standard chemotherapy. Only some of them can be delivered as monotherapy. The research on these new drugs is addressing both the identification of further target molecules in key cancer-related pathways and the improvement of drug effectiveness by changing the affinity and the selectivity of a moAb relative to its target.
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