Title
The cellular immune system in the post-myocardial infarction repair process The cellular immune system in the post-myocardial infarction repair process
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Amsterdam ,
Subject
Human medicine
Source (journal)
International journal of cardiology. - Amsterdam, 1981, currens
Volume/pages
179(2015) , p. 240-247
ISSN
0167-5273
ISI
000346089400069
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Growing evidence indicates that overactivation and prolongation of the inflammatory response after acute myocardial infarction (AMI) result in worse left ventricular remodelling, dysfunction and progression to heart failure. This post-AMI inflammatory response is characterised by the critical involvement of cells from both the innate and adaptive immune systems. In this review paper, we aim to summarise and discuss the emergence of immune cells in the bloodstream and myocardium after AMI in men and mice. Subset composition, phenotypes, and kinetics of immune cells are considered. In addition, the relation with post-MI cardiac remodelling, function and outcome is reported. Increased knowledge of immune components, the mechanisms and interactions by which these cells contribute to myocardial damage and repair following AMI may help to close the gaps that limit improvement of treatments of those who survive the acute infarction. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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https://repository.uantwerpen.be/docman/iruaauth/bf47c6/d8d122763.pdf
Handle