Title
The role of targeted therapy for gastrointestinal tumors The role of targeted therapy for gastrointestinal tumors
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
London :Expert reviews ,
Subject
Human medicine
Source (journal)
Expert review of gastroenterology & hepatology
Volume/pages
8(2014) :8 , p. 875-885
ISSN
1747-4124
ISI
000347182600005
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Many targeted drugs have been studied to target the molecular pathways involved in the development of gastrointestinal cancers. Anti-VEGF, anti-EGFR agents, and recently also multi-kinase inhibitor regorafenib, have already been available for the treatment of metastatic colorectal cancer patients. To date, Her-2 positive, gastric cancer patients, are also treated with trastuzumab, while the multi-targeted inhibitor, sorafenib, represents the standard treatment for hepatocellular carcinoma patients. Finally, sunitinib and everolimus, have been approved for the treatment of the neuroendocrine gastroenteropancreatic tumors. Actually a great number of further drugs are under preclinical and clinical development. The aim of this review is to provide a comprehensive overview of the state of art, focusing on the new emerging strategies in the personalized treatment of gastrointestinal tumors.
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