Title
Androgens inhibit the osteogenic response to mechanical loading in adult male mice Androgens inhibit the osteogenic response to mechanical loading in adult male mice
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Philadelphia, Pa ,
Subject
Human medicine
Source (journal)
Endocrinology. - Philadelphia, Pa
Volume/pages
156(2015) :4 , p. 1343-1353
ISSN
0013-7227
ISI
000353272700015
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Androgens are well known to enhance exercise-induced muscle hypertrophy, however whether androgens also influence bone's adapative response to mechanical loading remains unclear. We studied the adaptive osteogenic response to unilateral in vivo mechanical loading of tibia in adult male mice in both a long and a short term experimental set-up. Mice were divided in 4 groups: sham-operated, orchidectomized (ORX), testosterone (ORX+T) or non-aromatizable dihydrotestosterone (ORX+DHT) replacement. Significant interactions between androgen status and osteogenic response to mechanical loading were observed. Cortical thickness increased by T (0.14 vs. 0.11 mm sham, p<0.05) and DHT (0.17 vs. 0.11 mm sham, p<0.05). However, T partially (+36%) and DHT completely (+10%) failed to exhibit the loading-related increase observed in sham (+107%) and ORX (+131%, all p<0.05) mice. ORX decreased periosteal bone formation (PsBFR), which was restored to sham levels by T and DHT. However, both androgens completely suppressed the loading-related increase in PsBFR. Short term loading decreased the number of sclerostin positive osteocytes in sham, whereas in control fibulas, ORX decreased and T increased the number of sclerostin positive osteocytes. Loading no longer downregulated sclerostin in ORX or T groups.
E-info
https://repository.uantwerpen.be/docman/iruaauth/575cd1/157ef72b196.pdf
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