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Title
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Strength by joining methods : combining synthesis with NMR, IR, and vibrational circular dichroism spectroscopy for the determination of the relative configuration in hemicalide
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Author
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Abstract
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| The relative configuration of a key subunit of hemicalide, a recently isolated, highly bioactive marine natural product having potent antiproliferative activity against a panel of human cancer cell lines, was assigned by combining stereocontrolled synthesis of model substrates with NMR, IR, and vibrational circular dichroism (VCD) spectroscopy. The assignment of the absolute configuration of asymmetric carbon center C42 in two structurally complex epimeric substructures containing six stereocenters by VCD analysis illustrates the power and reliability of combining methods. |
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Language
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English
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Source (journal)
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Chemistry: a European journal. - Weinheim
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Publication
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Weinheim
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2014
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ISSN
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0947-6539
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DOI
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10.1002/CHEM.201404822
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Volume/pages
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20
:52
(2014)
, p. 17385-17394
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ISI
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000346468000018
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Full text (Publisher's DOI)
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Full text (open access)
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Full text (publisher's version - intranet only)
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