Publication
Title
Strength by joining methods : combining synthesis with NMR, IR, and vibrational circular dichroism spectroscopy for the determination of the relative configuration in hemicalide
Author
Abstract
The relative configuration of a key subunit of hemicalide, a recently isolated, highly bioactive marine natural product having potent antiproliferative activity against a panel of human cancer cell lines, was assigned by combining stereocontrolled synthesis of model substrates with NMR, IR, and vibrational circular dichroism (VCD) spectroscopy. The assignment of the absolute configuration of asymmetric carbon center C42 in two structurally complex epimeric substructures containing six stereocenters by VCD analysis illustrates the power and reliability of combining methods.
Language
English
Source (journal)
Chemistry: a European journal. - Weinheim
Publication
Weinheim : 2014
ISSN
0947-6539
Volume/pages
20:52(2014), p. 17385-17394
ISI
000346468000018
Full text (Publisher's DOI)
Full text (open access)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
[E?say:metaLocaldata.cgzprojectinf]
Development of experimental and theoretical methods used for the determination of the absolute configuration of chiral molecules: new approaches based upon a second generation Vibrational Circular Dichroism spectrometer.
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 09.03.2015
Last edited 04.10.2017
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