Title
HPLC-SPE-NMR characterization of major metabolites in **Salvia fruticosa** Mill. extract with antifungal potential : relevance of carnosic acid, carnosol, and hispidulin HPLC-SPE-NMR characterization of major metabolites in **Salvia fruticosa** Mill. extract with antifungal potential : relevance of carnosic acid, carnosol, and hispidulin
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Publication type
article
Publication
Washington, D.C. ,
Subject
Chemistry
Biology
Pharmacology. Therapy
Source (journal)
Journal of agricultural and food chemistry. - Washington, D.C.
Volume/pages
63(2015) :2 , p. 457-463
ISSN
0021-8561
ISI
000348332500011
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Plant pathogenic fungi are considered of significant economic importance for adversely affecting both quantitatively and qualitatively fresh and processed produce. Extracts of Salvia fruticosa were initially screened for their antifungal activity, and the ethyl acetate fraction, being the most active, was further analyzed using HPLC-SPE-NMR hyphenation. The methoxylated flavones hispidulin, salvigenin, and cirsimaritin and the diterpenes carnosic acid, carnosol, and 12-methoxycarnosic acid were identified as the major components of the extract. In addition, the concentration levels of all identified components were determined using q-NMR. The antifungal activity of the crude extract and selected phytochemicals was estimated against the fungal species Aspergillus tubingensis, Botrytis cinerea, and Penicillium digitatum. The estimated MIC and MFC values of the ethyl acetate extract of S. fruticosa, as well as three of its major constituents, carnosic acid, carnosol, and hispidulin, support their antifungal activity, especially against B. cinerea and P. digitatum, suggesting their potential use in food and agricultural systems.
E-info
https://repository.uantwerpen.be/docman/iruaauth/3bb901/641a3d8e79d.pdf
Full text (open access)
https://repository.uantwerpen.be/docman/irua/e9461f/9546.pdf
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