Publication
Title
Nodding syndrome-a new hypothesis and new direction for research
Author
Abstract
Nodding syndrome (NS) is an unexplained neurological illness that mainly affects children aged between 5 and 15 years. NS has so far been reported from South Sudan, northern Uganda, and Tanzania, but in spite of extensive investigations, the aetiology remains unknown. We hypothesize that blackflies (Diptera: Simuliidae) infected with Onchocerca volvulus microfilariae may also transmit another pathogen. This may be a novel neurotropic virus or an endosymbiont of the microfilariae, which causes not only NS, but also epilepsy without nodding. This hypothesis addresses many of the questions about NS that researchers have previously been unable to answer. An argument in favour of the hypothesis is the fact that in Uganda, the number of new NS cases decreased (with no new cases reported since 2013) after ivermectin coverage was increased and with the implementation of a programme of aerial spraying and larviciding of the large rivers where blackflies were breeding. If confirmed, our hypothesis will enable new strategies to control NS outbreaks. (C) 2014 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.
Language
English
Source (journal)
International journal of infectious diseases / International Society for Infectious Diseases. - Hamilton, Ont.
Publication
Hamilton, Ont. : 2014
ISSN
1201-9712
Volume/pages
27(2014), p. 74-77
ISI
000348023100018
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 13.03.2015
Last edited 11.07.2017
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