Title
Sensory neuron fates are distinguished by a transcriptional switch that regulates dendrite branch stabilizationSensory neuron fates are distinguished by a transcriptional switch that regulates dendrite branch stabilization
Author
Faculty/Department
Faculty of Sciences. Biology
Research group
Systemic Physiological and Ecotoxicological Research (SPHERE)
Publication type
article
Publication
Cambridge, Mass.,
Subject
Biology
Source (journal)
Neuron. - Cambridge, Mass.
Volume/pages
79(2013):2, p. 266-280
ISSN
0896-6273
ISI
000322426200007
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
Sensory neurons adopt distinct morphologies and functional modalities to mediate responses to specific stimuli. Transcription factors and their downstream effectors orchestrate this outcome but are incompletely defined. Here, we show that different classes of mechanosensory neurons in C. elegans are distinguished by the combined action of the transcription factors MEC-3, AHR-1, and ZAG-1. Low levels of MEC-3 specify the elaborate branching pattern of PVD nociceptors, whereas high MEC-3 is correlated with the simple morphology of AVM and PVM touch neurons. AHR-1 specifies AVM touch neuron fate by elevating MEC-3 while simultaneously blocking expression of nociceptive genes such as the MEC-3 target, the claudin-like membrane protein HPO-30, that promotes the complex dendritic branching pattern of PVD. ZAG-1 exercises a parallel role to prevent PVM from adopting the PVD fate. The conserved dendritic branching function of the Drosophila AHR-1 homolog, Spineless, argues for similar pathways in mammals.
E-info
https://repository.uantwerpen.be/docman/iruaauth/daed51/98c3091b3e6.pdf
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