Title
Identification of a bacterial inhibitor against g-type lysozyme Identification of a bacterial inhibitor against g-type lysozyme
Author
Faculty/Department
Faculty of Sciences. Biology
Publication type
article
Publication
Basel ,
Subject
Chemistry
Biology
Human medicine
Source (journal)
Cellular and molecular life sciences. - Basel
Volume/pages
68(2011) :6 , p. 1053-1064
ISSN
1420-682X
ISI
000287578700012
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
Lysozymes are antibacterial effectors of the innate immune system in animals that hydrolyze peptidoglycan. Bacteria have evolved protective mechanisms that contribute to lysozyme tolerance such as the production of lysozyme inhibitors, but only inhibitors of chicken (c-) and invertebrate (i-) type lysozyme have been identified. We here report the discovery of a novel Escherichia coli inhibitor specific for goose (g-) type lysozymes, which we designate PliG (periplasmic lysozyme inhibitor of g-type lysozyme). Although it does not inhibit c- or i-type lysozymes, PliG shares a structural sequence motif with the previously described PliI and MliC/PliC lysozyme inhibitor families, suggesting a common ancestry and mode of action. Deletion of pliG increased the sensitivity of E. coli to g-type lysozyme. The existence of inhibitors against all major types of animal lysozyme and their contribution to lysozyme tolerance suggest that lysozyme inhibitors may play a role in bacterial interactions with animal hosts.
E-info
https://repository.uantwerpen.be/docman/iruaauth/799410/0869643.pdf
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