Title
From the genome to the proteome : uncovering peptides in the Apis brainFrom the genome to the proteome : uncovering peptides in the Apis brain
Author
Faculty/Department
Faculty of Sciences. Biology
Publication type
article
Publication
Washington, D.C.,
Subject
Engineering sciences. Technology
Source (journal)
Science / American Association for the Advancement of Science. - Washington, D.C.
Volume/pages
314(2006):5799, p. 647-649
ISSN
0036-8075
ISI
000241557800047
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
Neuropeptides, critical brain peptides that modulate animal behavior by affecting the activity of almost every neuronal circuit, are inherently difficult to predict directly from a nascent genome sequence because of extensive posttranslational processing. The combination of bioinformatics and proteomics allows unprecedented neuropeptide discovery from an unannotated genome. Within the Apis mellifera genome, we have inferred more than 200 neuropeptides and have confirmed the sequences of 100 peptides. This study lays the groundwork for future molecular studies of Apis neuropeptides with the identification of 36 genes, 33 of which were previously unreported.
E-info
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