Title
Identification of a glycogenolysis-inhibiting peptide from the corpora cardiaca of locusts Identification of a glycogenolysis-inhibiting peptide from the corpora cardiaca of locusts
Author
Faculty/Department
Faculty of Sciences. Biology
Publication type
article
Publication
Philadelphia, Pa ,
Subject
Human medicine
Source (journal)
Endocrinology. - Philadelphia, Pa
Volume/pages
144(2003) :8 , p. 3441-3448
ISSN
0013-7227
ISI
000184258700023
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
A mass spectrometric study of the peptidome of the neurohemal part of the corpora cardiaca of Locusta migratoria and Schistocerca gregaria shows that it contains several unknown peptides. We were able to identify the sequence of one of these peptides as pQSDLFLLSPK. This sequence is identical to the part of the Locusta insulin-related peptide (IRP) precursor that is situated between the signal peptide and the B-chain. We designated this peptide as IRP copeptide. This IRP copeptide is also present in the pars intercerebralis, which is likely to be the site of synthesis. It is identical in both L. migratoria and S. gregaria. It shows no effect on the hemolymph lipid concentration in vivo or muscle contraction in vitro. The IRP copeptide is able to cause a decreased phosphorylase activity in locust fat body in vitro, opposite to the effect of the adipokinetic hormones and therefore possibly represents a glycogenolysis-inhibiting peptide.
E-info
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