Title
Formation of angiotensin-(1-7) from angiotensin II by the venom of **Conus geographus** Formation of angiotensin-(1-7) from angiotensin II by the venom of **Conus geographus**
Author
Faculty/Department
Faculty of Sciences. Biology
Publication type
article
Publication
Amsterdam ,
Subject
Human medicine
Source (journal)
Regulatory peptides. - Amsterdam
Volume/pages
105(2002) :2 , p. 101-108
ISSN
0167-0115
ISI
000174730600004
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
The binding of [H-3]angiotensin II to AT(1) receptors on Chinese Hamster Ovary cells expressing the human AT(1) receptor (CHO-AT(1) cells) is potently inhibited by venoms of the marine snails Conus geographus and C. betulinus. On the other hand, the binding of the nonpeptide AT(1) receptor-selective antagonist [H-3]candesartan is not affected but competition binding curves of angiotensin II and the peptide antagonist [Sar(1),Ile(8)]angiotensin II (sarile) are shifted to the right. These effects resulted from the breakdown of angiotensin II into smaller fragments that do not bind to the AT(1) receptor. In this context, angiotensin-(1-7) is the most prominent fragment and angiotensin-(1-4) and angiotensin-(1-5) are also formed but to a lesser extent. The molecular weight of the involved peptidases exceeds 50 kDa, as determined by gel chromatography and ultrafitration. (C) 2002 Published by Elsevier Science B.V.
E-info
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