Title
**Dracunculus medinensis** and **Schistosoma mansoni** contain opiate alkaloids**Dracunculus medinensis** and **Schistosoma mansoni** contain opiate alkaloids
Author
Faculty/Department
Faculty of Sciences. Biology
Publication type
article
Publication
Liverpool,
Subject
Human medicine
Source (journal)
Annals of tropical medicine and parasitology. - Liverpool, 1907 - 2011
Volume/pages
96(2002):3, p. 309-316
ISSN
0003-4983
ISI
000175559900008
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
The results of analysis, by high-performance liquid chromatography coupled with electrochemical detection and by nano-electrospray-ionization, double quadrupole orthogonal-acceleration, time-of-flight mass spectrometry, indicate that adult Dracunculus medinensis and Schistosoma mansoni both contain the opiate alkaloid morphine and that D. medinesis also contains the active metabolite of morphine, morphine 6-glucuronide. From these and previous observations, it would appear that many helminths are probably using opiate alkaloids as potent immuno suppressive and antinociceptive signal molecules, to down-regulate immune surveillance responsiveness and pain signalling in their hosts.
E-info
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