Publication
Title
**Dracunculus medinensis** and **Schistosoma mansoni** contain opiate alkaloids
Author
Abstract
The results of analysis, by high-performance liquid chromatography coupled with electrochemical detection and by nano-electrospray-ionization, double quadrupole orthogonal-acceleration, time-of-flight mass spectrometry, indicate that adult Dracunculus medinensis and Schistosoma mansoni both contain the opiate alkaloid morphine and that D. medinesis also contains the active metabolite of morphine, morphine 6-glucuronide. From these and previous observations, it would appear that many helminths are probably using opiate alkaloids as potent immuno suppressive and antinociceptive signal molecules, to down-regulate immune surveillance responsiveness and pain signalling in their hosts.
Language
English
Source (journal)
Annals of tropical medicine and parasitology. - Liverpool, 1907 - 2011
Publication
Liverpool : 2002
ISSN
0003-4983
Volume/pages
96:3(2002), p. 309-316
ISI
000175559900008
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Publication type
Subject
External links
Web of Science
Record
Identification
Creation 25.03.2015
Last edited 15.09.2017