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Title
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**Dracunculus medinensis** and **Schistosoma mansoni** contain opiate alkaloids
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Author
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Abstract
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| The results of analysis, by high-performance liquid chromatography coupled with electrochemical detection and by nano-electrospray-ionization, double quadrupole orthogonal-acceleration, time-of-flight mass spectrometry, indicate that adult Dracunculus medinensis and Schistosoma mansoni both contain the opiate alkaloid morphine and that D. medinesis also contains the active metabolite of morphine, morphine 6-glucuronide. From these and previous observations, it would appear that many helminths are probably using opiate alkaloids as potent immuno suppressive and antinociceptive signal molecules, to down-regulate immune surveillance responsiveness and pain signalling in their hosts. |
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Language
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English
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Source (journal)
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Annals of tropical medicine and parasitology. - Liverpool, 1907 - 2011
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Publication
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Liverpool
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2002
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ISSN
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0003-4983
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DOI
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10.1179/000349802125000808
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Volume/pages
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96
:3
(2002)
, p. 309-316
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ISI
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000175559900008
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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