Publication
Title
Presence of endogenous morphine and morphine 6 glucuronide in human heart tissue
Author
Abstract
Human atria contain the opiate alkaloids morphine and morphine 6 glucuronide as determined by high performance liquid chromatography coupled to electrochemical detection. This method found endogenous morphine and morphine 6 glucuronide at 106.28 +/- 61.58 and 48.32 +/- 24.63 (+/- SD) ng/gm wet weight, respectively. Identification of these opiates was confirmed by nano electrospray ionization double quadrupole orthogonal acceleration time of flight mass spectrometry. Furthermore, human saphenous Vein fragments did not contain morphine as determined by these methods. Fragmentation from a selected precursor ion by collision-induced dissociation of endogenous morphine 6 glucuronide (462.14 Da) yields morphine (286.14 Da) obtained from the heart tissues and with the authentic material, further demonstrating the presence of endogenous morphine. Thus, vascular tissues appear to contain endogenous opiate alkaloids.
Language
English
Source (journal)
International journal of molecular medicine. - Athens
Publication
Athens : 2001
ISSN
1107-3756
Volume/pages
7:4(2001), p. 419-422
ISI
000167690900014
UAntwerpen
Faculty/Department
Publication type
Subject
External links
Web of Science
Record
Identification
Creation 25.03.2015
Last edited 06.04.2017