Title
Comparison of the Mahalanobis distance and Pearson's <tex>$\chi^{2}$</tex> statistic as measures of similarity of isotope patterns Comparison of the Mahalanobis distance and Pearson's <tex>$\chi^{2}$</tex> statistic as measures of similarity of isotope patterns
Author
Faculty/Department
Faculty of Sciences. Chemistry
Publication type
article
Publication
New York, N.Y. ,
Subject
Chemistry
Biology
Source (journal)
Journal of the American Society for Mass Spectrometry. - New York, N.Y.
Volume/pages
25(2014) :2 , p. 293-296
ISSN
1044-0305
ISI
000330828700015
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
To extract a genuine peptide signal from a mass spectrum, an observed series of peaks at a particular mass can be compared with the isotope distribution expected for a peptide of that mass. To decide whether the observed series of peaks is similar to the isotope distribution, a similarity measure is needed. In this short communication, we investigate whether the Mahalanobis distance could be an alternative measure for the commonly employed Pearson's chi(2) statistic. We evaluate the performance of the two measures by using a controlled MALDI-TOF experiment. The results indicate that Pearson's chi(2) statistic has better discriminatory performance than the Mahalanobis distance and is a more robust measure.
E-info
https://repository.uantwerpen.be/docman/iruaauth/5e7ccc/4e09699.pdf
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000330828700015&DestLinkType=RelatedRecords&DestApp=ALL_WOS&UsrCustomerID=ef845e08c439e550330acc77c7d2d848
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000330828700015&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=ef845e08c439e550330acc77c7d2d848
Handle