Title Comparison of the Mahalanobis distance and Pearson's $\chi^{2}$ statistic as measures of similarity of isotope patterns Author Ghavidel, Fatemeh Zamanzad Claesen, Juergen Burzykowski, Tomasz Valkenborg, Dirk Faculty/Department Faculty of Sciences. Chemistry Publication type article Publication 2014 New York, N.Y. , 2014 Subject Chemistry Biology Source (journal) Journal of the American Society for Mass Spectrometry. - New York, N.Y. Volume/pages 25(2014) :2 , p. 293-296 ISSN 1044-0305 ISI 000330828700015 Carrier E Target language English (eng) Full text (Publishers DOI) Affiliation University of Antwerp Abstract To extract a genuine peptide signal from a mass spectrum, an observed series of peaks at a particular mass can be compared with the isotope distribution expected for a peptide of that mass. To decide whether the observed series of peaks is similar to the isotope distribution, a similarity measure is needed. In this short communication, we investigate whether the Mahalanobis distance could be an alternative measure for the commonly employed Pearson's chi(2) statistic. We evaluate the performance of the two measures by using a controlled MALDI-TOF experiment. The results indicate that Pearson's chi(2) statistic has better discriminatory performance than the Mahalanobis distance and is a more robust measure. E-info https://repository.uantwerpen.be/docman/iruaauth/5e7ccc/4e09699.pdf http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000330828700015&DestLinkType=RelatedRecords&DestApp=ALL_WOS&UsrCustomerID=ef845e08c439e550330acc77c7d2d848 http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000330828700015&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=ef845e08c439e550330acc77c7d2d848 Handle