Title
Phytochemical characterisation of a cytotoxic stem bark extract of **Steganotaenia araliacea** and identification of a protoflavanone by LCSPENMRPhytochemical characterisation of a cytotoxic stem bark extract of **Steganotaenia araliacea** and identification of a protoflavanone by LCSPENMR
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Faculty of Medicine and Health Sciences
Research group
Molecular Imaging, Pathology, Radiotherapy & Oncology (MIPRO)
Natural Products and Food - Research and Analysis (NatuRA)
Publication type
article
Publication
Subject
Chemistry
Biology
Pharmacology. Therapy
Source (journal)
Phytochemistry letters
Volume/pages
12(2015), p. 119-124
ISSN
1874-3900
ISI
000356336400022
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
A 80% ethanolic stem bark extract of Steganotaenia araliacea (Apiaceae) showed cytotoxic properties against MDA-MB-231 (breast), PANC-1 (pancreas) and HT-29 (colon) cancer cell lines. Phytochemical investigations by LC-SPE-NMR led to the identification of spiropreussomerin A, most probably produced by an endophytic fungus, the flavanonol conrauiflavonol / afzelin A, and a protoflavanone that has not been reported before and for which the name steganoprotoflavanone was adopted. Surprisingly none of the previously reported cytotoxic dibenzocyclo-octadiene lactone lignans was obtained as a major constituent of the cytotoxic extract.
E-info
https://repository.uantwerpen.be/docman/iruaauth/bf30ac/0ac3b615f5f.pdf
Full text (open access)
https://repository.uantwerpen.be/docman/irua/97bd63/9747.pdf
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