Publication
Title
Progressive methylation of ageing histones by Dot1 functions as a timer
Author
Abstract
Post-translational modifications of histone proteins have a crucial role in regulating gene expression. If efficiently re-established after chromosome duplication, histone modifications could help propagate gene expression patterns in dividing cells by epigenetic mechanisms. We used an integrated approach to investigate the dynamics of the conserved methylation of histone H3 Lys 79 (H3K79) by Dot1. Our results show that methylation of H3K79 progressively changes after histone deposition, which is incompatible with a rapid copy mechanism. Instead, methylation accumulates on ageing histones, providing the cell with a timer mechanism to directly couple cell-cycle length to changes in chromatin modification on the nucleosome core.
Language
English
Source (journal)
EMBO reports. - Oxford, 2000, currens
Publication
Oxford : 2011
ISSN
1469-221X
1469-3178 [online]
Volume/pages
12:9(2011), p. 956-962
ISI
000294476500019
Full text (Publisher's DOI)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
External links
Web of Science
Record
Identification
Creation 01.04.2015
Last edited 21.06.2017