Title
Progressive methylation of ageing histones by Dot1 functions as a timer
Author
Faculty/Department
Faculty of Sciences. Biology
Publication type
article
Publication
Oxford ,
Subject
Biology
Source (journal)
EMBO reports. - Oxford, 2000, currens
Volume/pages
12(2011) :9 , p. 956-962
ISSN
1469-221X
1469-3178
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
Post-translational modifications of histone proteins have a crucial role in regulating gene expression. If efficiently re-established after chromosome duplication, histone modifications could help propagate gene expression patterns in dividing cells by epigenetic mechanisms. We used an integrated approach to investigate the dynamics of the conserved methylation of histone H3 Lys 79 (H3K79) by Dot1. Our results show that methylation of H3K79 progressively changes after histone deposition, which is incompatible with a rapid copy mechanism. Instead, methylation accumulates on ageing histones, providing the cell with a timer mechanism to directly couple cell-cycle length to changes in chromatin modification on the nucleosome core.
E-info
https://repository.uantwerpen.be/docman/iruaauth/ed63eb/56160889c99.pdf