Title
The effect of human follicular fluid on bovine oocyte developmental competence and embryo quality
Author
Faculty/Department
Faculty of Sciences. Biology
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Veterinary Sciences
Publication type
article
Publication
Cambridge ,
Subject
Biology
Veterinary medicine
Human medicine
Source (journal)
Reproductive biomedicine online. - Cambridge
Volume/pages
30(2015) :2 , p. 203-207
ISSN
1472-6483
ISI
000349087000015
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
In this study, the hypothesis that embryo development during routine IVF procedures is determined by the pre-ovulatory follicular fluid composition was tested. Follicular fluid from women with obesity (obese) and a positive or negative IVF outcome was added during the in-vitro maturation of bovine oocytes. Negative and obese follicular fluid reduced bovine embryo development, compared with laboratory control embryo development (P < 0.05 or P < 0.1). The addition of follicular fluid also altered bovine blastocyst gene expression. Furthermore, LDHA and PPARGC1B gene expression differed between follicular fluid groups. Data suggest that pre-ovulatory follicular fluid can potentially affect oocyte developmental competence and embryo quality. Furthermore, the bovine model may be used as a screening tool.
E-info
https://repository.uantwerpen.be/docman/iruaauth/3599f8/cda75a2576d.pdf
Full text (open access)
https://repository.uantwerpen.be/docman/irua/7dd622/9769.pdf
E-info
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http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000349087000015&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=ef845e08c439e550330acc77c7d2d848
Handle