Title
The effect of human follicular fluid on bovine oocyte developmental competence and embryo quality The effect of human follicular fluid on bovine oocyte developmental competence and embryo quality
Author
Faculty/Department
Faculty of Sciences. Biology
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Veterinary Sciences
Publication type
article
Publication
Cambridge ,
Subject
Biology
Veterinary medicine
Human medicine
Source (journal)
Reproductive biomedicine online. - Cambridge
Volume/pages
30(2015) :2 , p. 203-207
ISSN
1472-6483
ISI
000349087000015
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
In this study, the hypothesis that embryo development during routine IVF procedures is determined by the pre-ovulatory follicular fluid composition was tested. Follicular fluid from women with obesity (obese) and a positive or negative IVF outcome was added during the in-vitro maturation of bovine oocytes. Negative and obese follicular fluid reduced bovine embryo development, compared with laboratory control embryo development (P < 0.05 or P < 0.1). The addition of follicular fluid also altered bovine blastocyst gene expression. Furthermore, LDHA and PPARGC1B gene expression differed between follicular fluid groups. Data suggest that pre-ovulatory follicular fluid can potentially affect oocyte developmental competence and embryo quality. Furthermore, the bovine model may be used as a screening tool.
E-info
https://repository.uantwerpen.be/docman/iruaauth/3599f8/cda75a2576d.pdf
Full text (open access)
https://repository.uantwerpen.be/docman/irua/7dd622/9769.pdf
E-info
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http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000349087000015&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=ef845e08c439e550330acc77c7d2d848
Handle