Title
Preclinical comparison of the amyloid-<tex>$\beta$</tex> radioligands [<tex>$^{11}C$</tex>]Pittsburgh compound B and [<tex>$^{18}F$</tex>]florbetaben in aged APPPS1-21 and BRI1-42 mouse models of cerebral amyloidosis Preclinical comparison of the amyloid-<tex>$\beta$</tex> radioligands [<tex>$^{11}C$</tex>]Pittsburgh compound B and [<tex>$^{18}F$</tex>]florbetaben in aged APPPS1-21 and BRI1-42 mouse models of cerebral amyloidosis
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
,
Subject
Human medicine
Computer. Automation
Source (journal)
Molecular imaging and biology. - Place of publication unknown
Volume/pages
17(2015) :5 , p. 688-696
ISSN
1536-1632
ISI
000361492000012
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Purpose The aim of this study was to compare [11C]Pittsburgh compound B ([11C]PiB) and [18F]florbetaben ([18F]FBB) for preclinical investigations of amyloid-β pathology. Procedures We investigated two aged animal models of cerebral amyloidosis with contrasting levels of amyloid-β relating to high (APPPS1-21 n = 6, wild type (WT) n = 7) and low (BRI1-42 n = 6, WT n = 6) target states, respectively. Results APPPS1-21 mice (high target state) demonstrated extensive fibrillar amyloid-β deposition that translated to significantly increased retention of [11C]PiB and [18F]FBB in comparison to their wild type. The retention pattern of [11C]PiB and [18F]FBB in this cohort displayed a significant correlation. However, the relative difference in tracer uptake between diseased and healthy mice was substantially higher for [11C]PiB than for [18F]FBB. Although immunohistochemistry confirmed the high plaque load in APPPS1-21 mice, correlation between tracer uptake and ex vivo quantification of amyloid-β was poor for both tracers. BRI1-42 mice (low target state) did not demonstrate increased tracer uptake. Conclusions In cases of high fibrillar amyloid-β burden, both tracers detected significant differences between diseased and healthy mice, with [11C]PiB showing a larger dynamic range.
E-info
https://repository.uantwerpen.be/docman/iruaauth/512416/de5426bed4b.pdf
Full text (open access)
https://repository.uantwerpen.be/docman/irua/2bb620/10899.pdf
E-info
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000361492000012&DestLinkType=RelatedRecords&DestApp=ALL_WOS&UsrCustomerID=ef845e08c439e550330acc77c7d2d848
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000361492000012&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=ef845e08c439e550330acc77c7d2d848
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000361492000012&DestLinkType=CitingArticles&DestApp=ALL_WOS&UsrCustomerID=ef845e08c439e550330acc77c7d2d848
Handle