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Title
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Preclinical comparison of the amyloid- radioligands []Pittsburgh compound B and []florbetaben in aged APPPS1-21 and BRI1-42 mouse models of cerebral amyloidosis
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Author
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Abstract
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| Purpose The aim of this study was to compare [11C]Pittsburgh compound B ([11C]PiB) and [18F]florbetaben ([18F]FBB) for preclinical investigations of amyloid-β pathology. Procedures We investigated two aged animal models of cerebral amyloidosis with contrasting levels of amyloid-β relating to high (APPPS1-21 n = 6, wild type (WT) n = 7) and low (BRI1-42 n = 6, WT n = 6) target states, respectively. Results APPPS1-21 mice (high target state) demonstrated extensive fibrillar amyloid-β deposition that translated to significantly increased retention of [11C]PiB and [18F]FBB in comparison to their wild type. The retention pattern of [11C]PiB and [18F]FBB in this cohort displayed a significant correlation. However, the relative difference in tracer uptake between diseased and healthy mice was substantially higher for [11C]PiB than for [18F]FBB. Although immunohistochemistry confirmed the high plaque load in APPPS1-21 mice, correlation between tracer uptake and ex vivo quantification of amyloid-β was poor for both tracers. BRI1-42 mice (low target state) did not demonstrate increased tracer uptake. Conclusions In cases of high fibrillar amyloid-β burden, both tracers detected significant differences between diseased and healthy mice, with [11C]PiB showing a larger dynamic range. |
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Language
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English
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Source (journal)
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Molecular imaging and biology. - Place of publication unknown
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Publication
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Place of publication unknown
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2015
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ISSN
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1536-1632
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DOI
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10.1007/S11307-015-0833-9
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Volume/pages
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17
:5
(2015)
, p. 688-696
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ISI
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000361492000012
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Pubmed ID
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25701131
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Full text (Publisher's DOI)
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Full text (open access)
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Full text (publisher's version - intranet only)
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