|
Title
|
|
|
|
Preclinical comparison of the amyloid- radioligands []Pittsburgh compound B and []florbetaben in aged APPPS1-21 and BRI1-42 mouse models of cerebral amyloidosis
|
|
|
Author
|
|
|
|
|
|
|
Abstract
|
|
|
|
| Purpose The aim of this study was to compare [11C]Pittsburgh compound B ([11C]PiB) and [18F]florbetaben ([18F]FBB) for preclinical investigations of amyloid-β pathology. Procedures We investigated two aged animal models of cerebral amyloidosis with contrasting levels of amyloid-β relating to high (APPPS1-21 n = 6, wild type (WT) n = 7) and low (BRI1-42 n = 6, WT n = 6) target states, respectively. Results APPPS1-21 mice (high target state) demonstrated extensive fibrillar amyloid-β deposition that translated to significantly increased retention of [11C]PiB and [18F]FBB in comparison to their wild type. The retention pattern of [11C]PiB and [18F]FBB in this cohort displayed a significant correlation. However, the relative difference in tracer uptake between diseased and healthy mice was substantially higher for [11C]PiB than for [18F]FBB. Although immunohistochemistry confirmed the high plaque load in APPPS1-21 mice, correlation between tracer uptake and ex vivo quantification of amyloid-β was poor for both tracers. BRI1-42 mice (low target state) did not demonstrate increased tracer uptake. Conclusions In cases of high fibrillar amyloid-β burden, both tracers detected significant differences between diseased and healthy mice, with [11C]PiB showing a larger dynamic range. |
|
|
|
Language
|
|
|
|
English
|
|
|
Source (journal)
|
|
|
|
Molecular imaging and biology. - New York, N.Y., 2002, currens
|
|
|
Publication
|
|
|
|
New York, N.Y.
:
Elsevier Science
,
2015
|
|
|
ISSN
|
|
|
|
1536-1632
[print]
1860-2002
[online]
|
|
|
DOI
|
|
|
|
10.1007/S11307-015-0833-9
|
|
|
Volume/pages
|
|
|
|
17
:5
(2015)
, p. 688-696
|
|
|
ISI
|
|
|
|
000361492000012
|
|
|
Pubmed ID
|
|
|
|
25701131
|
|
|
Full text (Publisher's DOI)
|
|
|
|
|
|
|
Full text (open access)
|
|
|
|
|
|
|
Full text (publisher's version - intranet only)
|
|
|
|
|
|