Title
CD4:8 ratio >5 is associated with a dominant naive t-cell phenotype and impaired physical functioning in CMV-seropositive very elderly people : results from the BELFRAIL study
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Springfield, Ill. ,
Subject
Human medicine
Source (journal)
Journals of gerontology : series A : biological sciences and medical sciences. - Springfield, Ill.
Volume/pages
70(2015) :2 , p. 143-154
ISSN
1079-5006
ISI
000350121100002
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
A subset of older people is at increased risk of hospitalization and dependency. Emerging evidence suggests that immunosenescence reflected by an inverted CD4:8 ratio and cytomegalovirus (CMV) seropositivity plays an important role in the pathophysiology of functional decline. Nevertheless, the relation between CD4:8 ratio and functional outcome has rarely been investigated. Here, CD4:8 ratio and T-cell phenotypes of 235 community-dwelling persons aged ≥81.5 years in the BELFRAIL study and 25 younger persons (mean age 28.5 years) were analyzed using polychromatic flow cytometry. In the elderly persons, 7.2% had an inverted CD4:8 ratio, which was associated with CMV seropositivity, less naive, and more late-differentiated CD4+ and CD8+ T cells. However, 32.8% had a CD4:8 ratio >5, a phenotype associated with a higher proportion of naive T cells and absent in young donors. In CMV seropositives, this subgroup had lower proportions of late-differentiated CD4+ and CD8+ T cells and weaker anti-CMV immunoglobulin G reactivity. This novel naive T-cell-dominated phenotype was counterintuitively associated with a higher proportion of those with impaired physical functioning in the very elderly people infected with CMV. This underscores the notion that in very elderly people, not merely CMV infection but also the state of its accompanying immune dysregulation is of crucial importance with regard to physical impairment.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/96d7cd/9896.pdf
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