Publication
Title
N-acylated sulfonamide congeners of fosmidomycin lack any inhibitory activity against DXR
Author
Abstract
The antibiotic fosmidomycin (3a) is an inhibitor of the non-mevalonate pathway for isoprenoid biosynthesis. Four analogues in which an acylated sulfonamide group is substituting for its phosphonate moiety have been synthesized in a fruitless effort to preserve one negative charge in order to increase the accompanying affinity for 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR), the fosmidomycin target enzyme.
Language
English
Source (journal)
Bioorganic and medicinal chemistry letters. - Oxford
Publication
Oxford : 2015
ISSN
0960-894X
Volume/pages
25:7(2015), p. 1577-1579
ISI
000351688700042
Full text (Publisher's DOI)
Full text (open access)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 27.04.2015
Last edited 17.06.2017
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