Title
|
|
|
|
N-acylated sulfonamide congeners of fosmidomycin lack any inhibitory activity against DXR
|
|
Author
|
|
|
|
|
|
Abstract
|
|
|
|
The antibiotic fosmidomycin (3a) is an inhibitor of the non-mevalonate pathway for isoprenoid biosynthesis. Four analogues in which an acylated sulfonamide group is substituting for its phosphonate moiety have been synthesized in a fruitless effort to preserve one negative charge in order to increase the accompanying affinity for 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR), the fosmidomycin target enzyme. |
|
|
Language
|
|
|
|
English
|
|
Source (journal)
|
|
|
|
Bioorganic and medicinal chemistry letters. - Oxford
|
|
Publication
|
|
|
|
Oxford
:
2015
|
|
ISSN
|
|
|
|
0960-894X
|
|
DOI
|
|
|
|
10.1016/J.BMCL.2015.02.006
|
|
Volume/pages
|
|
|
|
25
:7
(2015)
, p. 1577-1579
|
|
ISI
|
|
|
|
000351688700042
|
|
Pubmed ID
|
|
|
|
25726328
|
|
Full text (Publisher's DOI)
|
|
|
|
|
|
Full text (publisher's version - intranet only)
|
|
|
|
|
|