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Title
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Near-fatal persistent anion- and osmolal-gap acidosis due to massive gamma-butyrolactone/ethanol intoxication
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Author
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Abstract
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| We report a case of an ethanol and massive gamma-butyrolactone (GBL) intoxication, the precursor of the recreational drug gamma-hydroxybutyric acid (GHB), resulting in life-threatening metabolic acidosis (pH 6.5) with a highly increased anion- and osmolal gap. Rapid analysis using gas chromatography revealed a GHB plasma concentration of 4400 mg/L, far above the upper limit concentration of 1000 mg/L found in adult fatalities attributed to GBL. Full recovery was established following supportive treatment including haemodialysis. This is the first report of a combined ethanol/GBL intoxication as a cause of high serum anion- and osmolal-gap metabolic acidosis. |
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Language
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English
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Source (journal)
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Annals of clinical biochemistry. - London, 1969, currens
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Publication
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London
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2015
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ISSN
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0004-5632
[print]
1758-1001
[online]
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DOI
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10.1177/0004563214553278
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Volume/pages
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52
:2
(2015)
, p. 283-287
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ISI
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000350488000015
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Full text (Publisher's DOI)
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