Title
Cardiac endothelium-myocyte interaction : clinical opportunities for new heart failure therapies regardless of ejection fraction Cardiac endothelium-myocyte interaction : clinical opportunities for new heart failure therapies regardless of ejection fraction
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Publication type
article
Publication
London ,
Subject
Human medicine
Source (journal)
European heart journal. - London
Volume/pages
36(2015) :31 , p. 2050-+
ISSN
0195-668X
ISI
000360619200015
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Heart failure (HF) is an important global health problem with great socioeconomic burden. Outcomes remain sub-optimal. Endothelium cardiomyocyte interactions play essential roles in cardiovascular homeostasis, and deranged endothelium-related signalling pathways have been implicated in the pathophysiology of HF. In particular, disturbances in nitric oxide (NO)-mediated pathway and neuregulin-mediated pathway have been shown to contribute to the development of HF. These signalling pathways hold the potential as pathophysiological targets for new HF therapies, and may aid in patient selection for future HF trials.
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