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Title
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Cytomegalovirus seropositivity is associated with herpes zoster
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Author
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Abstract
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| Background Herpes zoster (HZ) is caused by VZV reactivation that is facilitated by a declined immunity against varicella-zoster virus (VZV), but also occurs in immunocompetent individuals. Cytomegalovirus (CMV) infection is associated with immunosenescence meaning that VZV-specific T-cells could be less responsive. Objectives This study aimed to determine whether CMV infection could be a risk factor for the development of HZ. Study design CMV IgG serostatus was determined in stored serum samples from previously prospectively recruited ambulatory adult HZ patients in the UK (N = 223) in order to compare the results with those from UK population samples (N = 1545) by means of a logistic regression (controlling for age and gender). Furthermore, we compared the UK population CMV seroprevalence with those from population samples from other countries (from Belgium (N1 = 1741, N2 = 576), USA (N = 5572) and Australia (N = 2080)). Furthermore, CMV IgG titers could be compared between UK HZ patients and Belgium N2 population samples because the same experimental set-up for analysis was used. Results We found UK ambulatory HZ patients to have a higher CMV seroprevalence than UK population samples (OR 1.56 [1.11 2.19]). CMV IgG seropositivity was a significant risk factor for HZ in the UK (OR 3.06 [1.32 7.04]. Furthermore, high CMV IgG titers (exceeding the upper threshold) were less abundant in CMV-seropositive Belgian N2 population samples than in CMV-seropositive UK HZ patients (OR 0.51 [0.31 0.82]. We found CMV-seroprevalence to increase faster with age in the UK than in other countries (P < 0.05). Conclusions We conclude that CMV IgG seropositivity is associated with HZ. This finding could add to the growing list of risk factors for HZ. |
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Language
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English
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Source (journal)
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Human vaccines & immunotherapeutics. - Philadelphia, Pa, 2012, currens
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Publication
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Philadelphia, Pa
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2015
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ISSN
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2164-5515
[print]
2164-554X
[online]
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DOI
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10.1080/21645515.2015.1037999
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Volume/pages
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11
:6
(2015)
, p. 1394-1399
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ISI
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000356426800026
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Pubmed ID
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25905443
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Full text (Publisher's DOI)
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