Title
<tex>$\alpha$</tex>-Synuclein strains cause distinct synucleinopathies after local and systemic administration <tex>$\alpha$</tex>-Synuclein strains cause distinct synucleinopathies after local and systemic administration
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
London ,
Subject
Biology
Human medicine
Engineering sciences. Technology
Source (journal)
Nature. - London
Volume/pages
522(2015) :7556 , p. 340-344
ISSN
0028-0836
ISI
000356425400053
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Misfolded protein aggregates represent a continuum with overlapping features in neurodegenerative diseases but differences in protein components and affected brain regions1. The molecular hallmark of synucleinopathies such as Parkinsons Disease (PD), Dementia with Lewy Bodies (DLB) and Multiple System Atrophy (MSA) are mega-dalton α-synuclein-rich deposits suggestive of one molecular event causing distinct disease phenotypes. Glial α-synuclein (αSYN) filamentous deposits are prominent in MSA while neuronal αSYN inclusions are found in PD and DLB2. The recent discovery of αSYN assemblies with different structural characteristics or strains has led to the hypothesis that strains could provide an explanation for the different clinico-pathological traits within synucleinopathies3,4. In this study we show that αSYN strain conformation and seeding propensity lead to distinct histopathological and behavioral phenotypes. We assess the properties of structurally well-defined αSYN assemblies (oligomers, ribbons and fibrils) after injection in rat brain. We prove that αSYN strains amplify in vivo. Fibrils appear as the major toxic species resulting in progressive motor impairment and cell death, while ribbons cause a distinct histopathological phenotype displaying PD and MSA traits. Additionally, we show that αSYN assemblies cross the blood-brain barrier and distribute to the central nervous system after intravenous injection. Our results demonstrate that distinct αSYN strains display differential seeding capacities inducing strain-specific pathology and neurotoxic phenotypes.
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https://repository.uantwerpen.be/docman/iruaauth/3840a7/125363.pdf
Handle