Title
Plasmonic nanodiamonds : targeted coreshell type nanoparticles for cancer cell thermoablation Plasmonic nanodiamonds : targeted coreshell type nanoparticles for cancer cell thermoablation
Author
Faculty/Department
Faculty of Sciences. Physics
Publication type
article
Publication
Subject
Physics
Chemistry
Human medicine
Source (journal)
Advanced healthcare materials
Volume/pages
4(2015) :3 , p. 460-468
ISSN
2192-2640
2192-2659
ISI
000349961600014
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Targeted biocompatible nanostructures with controlled plasmonic and morphological parameters are promising materials for cancer treatment based on selective thermal ablation of cells. Here, coreshell plasmonic nanodiamonds consisting of a silica-encapsulated diamond nanocrystal coated in a gold shell are designed and synthesized. The architecture of particles is analyzed and confirmed in detail using electron tomography. The particles are biocompatibilized using a PEG polymer terminated with bioorthogonally reactive alkyne groups. Azide-modified transferrin is attached to these particles, and their high colloidal stability and successful targeting to cancer cells overexpressing the transferrin receptor are demonstrated. The particles are nontoxic to the cells and they are readily internalized upon binding to the transferrin receptor. The high plasmonic cross section of the particles in the near-infrared region is utilized to quantitatively ablate the cancer cells with a short, one-minute irradiation by a pulse 750-nm laser.
E-info
https://repository.uantwerpen.be/docman/iruaauth/892968/3f946663186.pdf
Full text (open access)
https://repository.uantwerpen.be/docman/irua/aeb915/9924.pdf
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