Title
In vitro human metabolism of the flame retardant resorcinol bis(diphenylphosphate) (RDP)
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Publication type
article
Publication
Easton, Pa ,
Subject
Chemistry
Biology
Source (journal)
Environmental science and technology / American Chemical Society. - Easton, Pa
Volume/pages
49(2015) :6 , p. 3897-3904
ISSN
0013-936X
ISI
000351324400074
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Resorcinol bis(diphenylphosphate) (RDP) is widely used as a flame retardant in electrical/electronic products and constitutes a suitable alternative to decabrominated diphenyl ether. Due to its toxicity and its recently reported ubiquity in electronics and house dust, there are increasing concerns about human exposure to this emerging contaminant. With the aim of identifying human-specific biomarkers, the in vitro metabolism of RDP and its oligomers was investigated using human liver microsomes and human liver cytosol. Mono- and dihydroxy-metabolites, together with gluc-uronidated and sulfated metabolites, were detected. Regarding RDP oligomers, only a hydroxymetabolite of the dimer could be detected. RDP and its oligomers were also readily hydrolyzed, giving rise to a variety of compounds, such as diphenyl phosphate, para-hydroxy-triphenyl phosphate, and para-hydroxy RDP, which were further metabolized. These degradation products or impurities are possibly of environmental importance in future studies.
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Full text (open access)
https://repository.uantwerpen.be/docman/irua/c4a2eb/125514.pdf
E-info
https://repository.uantwerpen.be/docman/iruaauth/2efc76/125514.pdf
Handle