Publication
Title
Helical tomotherapy in head and neck cancer : a European single-center experience
Author
Abstract
Background. We report on a retrospective analysis of 147 patients with early and locoregionally advanced squamous cell head and neck cancer (SCCHN) treated with helical tomotherapy (HT). Patients and Methods. Included were patients with SCCHN of theoral cavity (OC), oropharynx (OP), hypopharynx (HP), or larynx (L) consecutively treated in one radiotherapy center in 2008 and 2009. The prescribed HT dose was 60-66 Gy in the postoperative setting (group A) and 66-70 Gy when given as primary treatment (group B). HT was given alone, concurrent with systemic therapy (ST), that is, chemotherapy, biotherapy, or both, and with or without induction therapy (IT). Acute and late toxicities are reported using standard criteria; locoregional failure/progression (LRF), distant metastases (DM), and second primary tumors (SPT) were documented, and event-free survival (EFS) and overall survival (OS) were calculated from the start of HT. Results. Group A patients received HT alone in 22 cases and HT+ST in 20 cases; group B patients received HT alone in 17 cases and HT 1 ST in 88 cases. Severe (grade >= 3) acute mucosal toxicity and swallowing problems increased with more additional ST. After a median follow-up of 44 months, grade >= 2 late toxicity after HT+ST was approximately twice that of HT alone for skin, subcutis, pharynx, and larynx. Forty percent had grade >= 2 late xerostomia, and 29% hadmucosal toxicity. At 3 years, LRF/DM/SPT occurred in 7%/7%/17% and 25%/13%/5% in groups A and B, respectively, leading to a 3-year EFS/OS of 64%/74% and 56%/63% in groups A and B, respectively. Conclusion. The use of HT alone or in combination with ST is feasible and promising and has a low late fatality rate. However, late toxicity is nearly twice as high when ST is added to HT.
Language
English
Source (journal)
The oncologist. - Place of publication unknown
Publication
Place of publication unknown : 2015
ISSN
1083-7159
Volume/pages
20:3(2015), p. 279-290
ISI
000351919500011
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 12.05.2015
Last edited 30.07.2017
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