Title
Urinary phthalate metabolites are associated with insulin resistance in obese subjects Urinary phthalate metabolites are associated with insulin resistance in obese subjects
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Subject
Chemistry
Biology
Human medicine
Source (journal)
Environmental research
Volume/pages
137(2015) , p. 419-423
ISSN
0013-9351
ISI
000352331000050
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Phthalates are potentially involved in the development of type 2 diabetes mellitus. In a cohort of 123 obese subjects, 10 phthalate metabolites were analyzed. An oral glucose tolerance test was performed and various estimates of insulin resistance and beta-cell function were calculated. After adjustment for age, physical activity level, smoking behavior, medication use and body mass index, several phthalate metabolites were linked to markers of glucose tolerance and insulin resistance. (C) 2015 Elsevier Inc. All rights reserved.
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