The role of immunotherapy in colorectal cancerThe role of immunotherapy in colorectal cancer
Faculty of Medicine and Health Sciences
Molecular Imaging, Pathology, Radiotherapy & Oncology (MIPRO)
Belgian journal of medical oncology. - Amsterdam, 2007, currens
9(2015):1, p. 25-30
University of Antwerp
Colorectal cancer is one of the most prevalent types of cancer worldwide and a leading cause of cancer related mortality. Although chemo- and radiation therapy can improve survival rates, it is imperative to integrate more advanced treatment options; therefore, rationally designed immunotherapeutic strategies are being explored as adjuvant treatment. In this review, we will discuss the study design and results of the clinical trials that have been conducted in colorectal cancer patients using autologous and allogeneic tumour cell vaccines, peptide vaccines, viral vector based vaccines, dendritic cell based vaccines, and antibody-based immunotherapy as well as some future recommendations.