Title
C-terminal neurogranin is increased in CSF but unchanged in plasma in Alzheimer's disease C-terminal neurogranin is increased in CSF but unchanged in plasma in Alzheimer's disease
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
,
Subject
Biology
Human medicine
Source (journal)
Alzheimer's & dementia. - Place of publication unknown
Volume/pages
11(2015) :12 , p. 1461-1469
ISSN
1552-5260
ISI
000366721600007
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Background: Biomarkers monitoring synaptic degeneration/loss would be valuable for Alzheimers disease (AD) diagnosis. Post-synaptic protein neurogranin may be a promising CSF biomarker but has not yet been evaluated as plasma biomarker. Methods: Using an in-house designed prototype ELISA targeting neurogranin C-terminally, we studied neurogranin in paired CSF/plasma samples of controls (n=29) versus patients experiencing MCI, or dementia, due to AD (in total n=59). Results: CSF neurogranin was increased in AD and positively correlated with CSF tau while there was a negative relationship between CSF neurogranin (and tau) and CSF Aβ1-42/Aβ1-40. No differences were detected in plasma neurogranin between controls and AD. Also, there was no correlation between CSF and plasma neurogranin, excluding confounding effects of the latter. Conclusions: This study strengthens the potential of neurogranin as an AD CSF biomarker, which now needs validation in larger studies. As tools, straightforward immuno-assays can be used, as demonstrated by the described ELISA.
E-info
https://repository.uantwerpen.be/docman/iruaauth/13d67b/125766.pdf
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