Title
Alternative clinical trial design in neurocritical care Alternative clinical trial design in neurocritical care
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Totowa :Humana press inc ,
Subject
Human medicine
Source (journal)
Neurocritical care
Volume/pages
22(2015) :3 , p. 378-384
ISSN
1541-6933
ISI
000354196300006
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Neurocritical care involves the care of highly complex patients with combinations of physiologic derangements in the brain and in extracranial organs. The level of evidence underpinning treatment recommendations remains low due to a multitude of reasons including an incomplete understanding of the involved physiology; lack of good quality, prospective, standardized data; and the limited success of conventional randomized controlled trials. Comparative effectiveness research can provide alternative perspectives and methods to enhance knowledge and evidence within the field of neurocritical care; these include large international collaborations for generation and maintenance of high quality data, statistical methods that incorporate heterogeneity and individualize outcome prediction, and finally advanced bioinformatics that integrate large amounts of variable-source data into patient-specific phenotypes and trajectories.
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