Title
Panitumumab in metastatic colorectal cancer : the importance of tumour RAS status Panitumumab in metastatic colorectal cancer : the importance of tumour RAS status
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Northcote :Adis int ltd ,
Subject
Pharmacology. Therapy
Source (journal)
Drugs. - London
Volume/pages
75(2015) :7 , p. 731-748
ISSN
0012-6667
ISI
000354199500003
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Tumour biomarker status is being used more and more frequently to guide treatment decisions in patients with metastatic colorectal cancer (mCRC). Continued cycles of hypothesis generation and biomarker testing in retrospective, prospective-retrospective and prospective analyses from studies of the epidermal growth factor (EGFR)-targeted monoclonal antibodies (mAbs), panitumumab and cetuximab, have resulted in improved patient selection in mCRC. Initial data suggested EGFR-targeted mAb treatment should be limited to patients with KRAS exon 2 wild-type (WT) tumours, but the availability of tumour samples from large phase III studies permitted evaluation of additional potential biomarkers of activity for these agents. Subsequent analyses further refined the target population to those patients whose tumours were WT for KRAS and NRAS exons 2, 3 and 4 (i.e., those with RAS WT status). Here, we review key clinical data for panitumumab in mCRC across the lines of treatment, assessing in detail the impact of more comprehensive RAS selection on patient outcomes. Panitumumab data across first- to third-line therapy consistently demonstrate that by testing tumour RAS status, it is possible to select patients more likely to benefit from treatment.
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Full text (open access)
https://repository.uantwerpen.be/docman/irua/18d8cb/126051.pdf
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