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Title
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Prucalopride for constipation
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Author
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Abstract
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| Importance of the field: Chronic constipation has a high prevalence, and current medical and pharmacological therapies do not restore normal bowel function in all patients. Areas covered in the review: A PubMed search (1965 2009) using the following terms alone or in combination: prucalopride, 5-HT4, R093877, safety, toxicity, pharmacokinetics, pharmacodynamics, transit, cardiac, hERG, arrhythmia, potassium current, elderly. What the reader will gain: Understanding of the mechanisms of action, safety, efficacy and indications for prucalopride in patients with chronic constipation. Take home message: Prucalopride is an efficacious and generally safe, new therapeutic option in the management of chronic constipation. |
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Language
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French
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Source (journal)
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Expert opinion on pharmacotherapy. - London
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Publication
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London
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2010
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ISSN
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1465-6566
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DOI
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10.1517/14656560903567057
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Volume/pages
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11
:3
(2010)
, p. 451-461
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ISI
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000276194700010
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Full text (Publisher's DOI)
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