Publication
Title
Matrix metalloproteinases in head and neck cancer
Author
Abstract
Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases, which degrade all kinds of extracellular matrix proteins. MMPs play an important role in cell behaviors such as proliferation, migration, differentiation, apoptosis, and host defense. Polymorphisms in the promoter regions of multiple MMPs and overexpression of MMPs and tissue inhibitors of metalloproteinases (TIMPs) are associated with head and neck cancer risk, higher T and N stage, and a worse prognosis. Serum and plasma levels of MMP and TIMP might be useful in diagnostics and follow-up. However, their use as therapeutic target should be further investigated, since the antitumor activity of matrix metalloproteinase inhibitors has been disappointing thus far.
Language
English
Source (journal)
World journal of surgical, medical and radiation oncology
Publication
2015
Volume/pages
4(2015), p. 18-27
Full text (open access)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Record
Identification
Creation 03.07.2015
Last edited 04.07.2015
To cite this reference