Title
Docetaxel (Taxotere <tex>$^{TM}),$</tex> a review of preclinical and clinical experience: part 2: clinical experience Docetaxel (Taxotere <tex>$^{TM}),$</tex> a review of preclinical and clinical experience: part 2: clinical experience
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Philadelphia, Pa ,
Subject
Pharmacology. Therapy
Human medicine
Source (journal)
Anti-cancer drugs: an international journal on anti-cancer agents. - Philadelphia, Pa
Volume/pages
6(1995) :3 , p. 356-368
ISSN
0959-4973
ISI
A1995RB82500002
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Docetaxel, a promising inhibitor of microtubule depolymerization has shown significant anti-cancer activity during phase I and early phase II trials. The recommended dosage for phase II trials is 100 mg/m(2) every 3 weeks which provides optimal activity with tolerable adverse effects. Decetaxel has shown high single agent activity including use as first- or second-line therapy and in anthracycline refractory breast cancer patients. Results have been comparable to that of established treatments for breast cancer. In addition, docetaxel has shown significant activity in non-small cell lung cancer and a range of other tumors, but no activity in renal or cole-rectal tumors. At present it is undergoing further evaluation in combination therapy. The safety profile of docetaxel is well defined. Major adverse effects include hypersensitivity reactions, fluid retention and neutropenia. Peripheral neuropathy is not a significant adverse effect. The aims of phase II trials with regard to counteracting side-effects are therefore 5-fold: firstly, to evaluate the use of premedication with corticosteroids and antihistamines as a means of counteracting hypersensitivity reactions and fluid retention; secondly, to determine whether granulocyte colony stimulating factor may be useful for attenuating neutropenia.
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