Title
Long-term remission of locally recurrent oropharyngeal cancer after docetaxel-based chemotherapy plus cetuximabLong-term remission of locally recurrent oropharyngeal cancer after docetaxel-based chemotherapy plus cetuximab
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Research group
Anatomopathologie
Translational Neurosciences (TNW)
Molecular Imaging, Pathology, Radiotherapy & Oncology (MIPRO)
Faculteit Geneeskunde
Publication type
article
Publication
Berlin,
Subject
Human medicine
Source (journal)
European archives of oto-rhino-laryngology. - Berlin, 1990, currens
Volume/pages
273(2016):6, p. 1629-1636
ISSN
0937-4477
ISI
000375607700038
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Background In recurrent head and neck squamous cell carcinoma ineligible for resection or irradiation, treatment aims primarily at symptom control and quality of life enhancement with an expected outcome of 612 months. Methods In 2005, a male patient, born in 1944, with a second local recurrence of human papillomavirus negative tonsil cancer was enrolled in the EXTREME trial, and randomized to platinum/5-fluorouracil/cetuximab arm resulting in partial remission with progression-free survival of 12 months. The second-line systemic therapy comprised 5 cycles of 3-weekly docetaxel/cisplatin/5-fluorouracil regimen plus weekly cetuximab. Results As confirmed on imaging and repeated biopsies, complete response was achieved with disease-free survival of 8 years and follow-up period of 12 years. Severe acute toxicities during the taxane-based chemotherapy plus cetuximab included grade 4 anorexia and grade 3 febrile neutropenia. Conclusions Poor tumor differentiation, no weight loss, oropharyngeal location, white race, and particularly the induced complete response were most likely the key favorable prognostic factors in the reported patient. The possibility of a synergistic interaction between taxanes and cetuximab should be further explored.
E-info
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