Title
Rehabilitation in patients with radically treated respiratory cancer : a randomised controlled trial comparing two training modalities
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Amsterdam ,
Subject
Human medicine
Source (journal)
Lung cancer: journal of the International Association for the Study of Lung Cancer / International Association for the Study of Lung Cancer [Aurora, Colo.] - Amsterdam
Volume/pages
89(2015) :2 , p. 167-174
ISSN
0169-5002
ISI
000358390000013
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Introduction: The evidence on the effectiveness of rehabilitation in lung cancer patients is limited. Whole body vibration (WBV) has been proposed as an alternative to conventional resistance training (CRT). Methods: We investigated the effect of radical treatment (RT) and of two rehabilitation programmes in lung cancer patients. The primary endpoint was a change in 6-min walking distance (6MWD) after rehabilitation. Patients were randomised after RT to either CRT, WBVT or standard follow-up (CON). Patients were evaluated before, after RT and after 12 weeks of intervention. Results: Of 121 included patients, 70 were randomised to either CON (24), CRT (24) or WBVT (22). After RT, 6MWD decreased with a mean of 38 m (95% CI 22-54) and increased with a mean of 95 m (95% CI 58-132) in CRT (p < 0.0001), 37m (95% CI -1-76) in WBVT (p = 0.06) and 1 m (95% CI -34-36) in CON (p = 0.95), respectively. Surgical treatment, magnitude of decrease in 6MWD by RT and allocation to either CRT or WBVT were prognostic for reaching the minimally clinically important difference of 54 m increase in 6MWD after intervention. Conclusions: RT of lung cancer significantly impairs patients' exercise capacity. CRT significantly improves and restores functional exercise capacity, whereas WBVT does not fully substitute for CRT. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
E-info
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https://repository.uantwerpen.be/docman/iruaauth/f99035/704127148.pdf
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