Title
Positron emission tomography (PET) quantification of <tex>$GABA_{A}$</tex> receptors in the brain of fragile X patients Positron emission tomography (PET) quantification of <tex>$GABA_{A}$</tex> receptors in the brain of fragile X patients
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
Subject
Engineering sciences. Technology
Source (journal)
PLoS ONE
Volume/pages
10(2015) :7 , 12 p.
ISSN
1932-6203
1932-6203
Article Reference
e0131486
Carrier
E-only publicatie
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Over the last several years, evidence has accumulated that the GABA(A) receptor is compromised in animal models for fragile X syndrome (FXS), a common hereditary form of intellectual disability. In mouse and fly models, agonists of the GABA(A) receptor were able to rescue specific consequences of the fragile X mutation. Here, we imaged and quantified GABA(A) receptors in vivo in brain of fragile X patients using Positron Emission Topography (PET) and [C-11] flumazenil, a known high-affinity and specific ligand for the benzodiazepine site of GABA(A) receptors. We measured regional GABA(A) receptor availability in 10 fragile X patients and 10 control subjects. We found a significant reduction of on average 10% in GABA(A) receptor binding potential throughout the brain in fragile X patients. In the thalamus, the brain region showing the largest difference, the GABA(A) receptor availability was even reduced with 17%. This is one of the first reports of a PET study of human fragile X brain and directly demonstrates that the GABA(A) receptor availability is reduced in fragile X patients. The study reinforces previous hypotheses that the GABA(A) receptor is a potential target for rational pharmacological treatment of fragile X syndrome.
E-info
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Full text (open access)
https://repository.uantwerpen.be/docman/irua/39a03d/127223.pdf
E-info
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Handle