Title
Endoscopic versus transcranial procurement of allograft tympano-ossicular systems : a prospective double-blind randomized controlled auditEndoscopic versus transcranial procurement of allograft tympano-ossicular systems : a prospective double-blind randomized controlled audit
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Research group
Vaccine & Infectious Disease Institute (VAXINFECTIO)
Translational Neurosciences (TNW)
Faculteit Geneeskunde
Publication type
article
Publication
London,
Subject
Biology
Human medicine
Source (journal)
Cell and tissue banking. - London, 2000, currens
Volume/pages
17(2016):2, p. 199-204
ISSN
1389-9333
ISI
000376988400003
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Allograft tympano-ossicular systems (ATOS) have proven their use over many decades in tympanoplasty and reconstruction after resection of cholesteatoma. The transcranial bone plug technique has been used in the past 50 years to procure en bloc ATOS (tympanic membrane with malleus, incus and stapes attached). Recently, our group reported the feasibility of the endoscopic procurement technique. The aim of this study was to assess whether clinical outcome is equivalent in ATOS acquired by using the endoscopic procurement technique compared to ATOS acquired by using the transcranial technique. A double-blind randomized controlled audit was performed in a tertiary referral center in patients that underwent allograft tympanoplasty because of chronic otitis media with and without cholesteatoma. Allograft epithelialisation was evaluated at the short-term postoperative visit by microscopic examination. Failures were reported if reperforation was observed. Fifty patients underwent allograft tympanoplasty: 34 received endoscopically procured ATOS and 16 received transcranially procured ATOS. One failed case was observed, in the endoscopic procurement group. We did not observe a statistically significant difference between the two groups in failure rate. This study demonstrates equivalence of the clinical outcome of allograft tympanoplasty using either endoscopic or transcranial procured ATOS and therefore indicates that the endoscopic technique can be considered the new standard procurement technique. Especially because the endoscopic procurement technique has several advantages compared to the former transcranial procurement technique: it avoids risk of prion transmission and it is faster while lacking any noticeable incision.
E-info
https://repository.uantwerpen.be/docman/iruaauth/e1f524/7ef39e46c43.pdf
Full text (open access)
https://repository.uantwerpen.be/docman/irua/72dec7/10703.pdf
E-info
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Handle