Title
Cerebral and cerebellar language organization in a right-handed subject with a left temporal porencephalic cyst : an fMRI study Cerebral and cerebellar language organization in a right-handed subject with a left temporal porencephalic cyst : an fMRI study
Author
Faculty/Department
Faculty of Sciences. Physics
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
Oxford ,
Subject
Psychology
Human medicine
Linguistics
Source (journal)
Journal of neurolinguistics. - Oxford
Volume/pages
37(2016) , p. 41-46
ISSN
0911-6044
ISI
000366228000005
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
To test the hypothesis of crossed cerebro-cerebellar language dominance (Mariën, Engelborghs, Fabbro, & De Deyn, 2001) in atypical populations, the pattern of cerebral and cerebellar language organization in a right-handed woman with a large porencephalic cyst in the left temporal lobe with no secondary clinical neurological symptoms was studied by means of an fMRI-language paradigm. Extensive neuropsychological examinations were performed to formally rule out cognitive dysfunctions. The fMRI task, consisting of a covert controlled oral word generation task, disclosed a pattern of bilateral activity in the frontal language areas, slightly more pronounced in the left hemisphere, and unilateral activation of the left inferior and superior temporal and supramarginal gyrus. This pattern of supratentorial activations was reflected at the infratentorial level by bilateral activations in the posterior lobe of the cerebellum with slightly more activity located in the right cerebellar hemisphere. This pattern of bilateral cerebral and cerebellar activation seems to confirm that the distribution of supratentorial language dominance is intrinsically reflected at the level of the cerebellum. Bilateral frontal language representation might be the consequence of neurofunctional compensation for the structural anomaly affecting eloquent brain regions resulting in an operational inefficiency of the neural network subserving language in the left hemisphere.
E-info
https://repository.uantwerpen.be/docman/iruaauth/012e29/bc065f08b6d.pdf
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