Title
Performance and complications of lumbar puncture in memory clinics : results of the multicenter lumbar puncture feasibility study Performance and complications of lumbar puncture in memory clinics : results of the multicenter lumbar puncture feasibility study
Author
Faculty/Department
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
,
Subject
Human medicine
Source (journal)
Alzheimer's & dementia. - Place of publication unknown
Volume/pages
12(2016) :2 , p. 154-163
ISSN
1552-5260
ISI
000369523500007
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Introduction Lumbar puncture (LP) is increasingly performed in memory clinics. We investigated patient-acceptance of LP, incidence of and risk factors for post-LP complications in memory clinic populations. Methods We prospectively enrolled 3868 patients (50% women, age 66 ± 11 years, mini mental state examination 25 ± 5) at 23 memory clinics. We used logistic regression analysis using generalized estimated equations to investigate risk factors for post-LP complications, such as typical postlumbar puncture headache (PLPH) and back pain. Results A total of 1065 patients (31%) reported post-LP complaints; 589 patients (17%) reported back pain, 649 (19%) headache, of which 296 (9%) reported typical PLPH. Only few patients needed medical intervention: 11 (0.3%) received a blood patch, 23 (0.7%) were hospitalized. The most important risk factor for PLPH was medical history of headache. An atraumatic needle and age >65 years were preventive. Gender, rest after LP, or volume of cerebrospinal fluid had no effect. Conclusions The overall risk of complications is relatively low. If risk factors shown in this study are taken into account, LPs can be safely performed in memory clinics.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/b8bfad/10794.pdf
https://repository.uantwerpen.be/docman/irua/ba0805/10795.pdf
https://repository.uantwerpen.be/docman/irua/ce6b58/10797.pdf
https://repository.uantwerpen.be/docman/irua/baa396/10798.pdf
https://repository.uantwerpen.be/docman/irua/7ad5ad/10799.pdf
E-info
https://repository.uantwerpen.be/docman/iruaauth/5e4105/127674.pdf
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