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Title
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Empowering gamma delta T cells with antitumor immunity by dendritic cell-based immunotherapy
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Author
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Abstract
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| Gamma delta (γδ) T cells are the all-rounders of our immune-system with their major histocompatibility complex-unrestricted cytotoxicity, capacity to secrete immunosti-mulatory cytokines and ability to promote the generation of tumor antigen-specific CD8+ and CD4+ T cell responses. Dendritic cell (DC)-based vaccine therapy has the prospective to harness these unique features of the γδ T cells in the fight against cancer. In this review, we will discuss our current knowledge on DC-mediated γδ T cell activation and related opportunities for tumor immunologists. |
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Language
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English
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Source (journal)
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Oncoimmunology
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Publication
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2015
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ISSN
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2162-4011
2162-402X
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DOI
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10.1080/2162402X.2015.1021538
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Volume/pages
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4
:8
(2015)
, 9 p.
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Article Reference
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e1021538
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ISI
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000360239300013
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Medium
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E-only publicatie
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Full text (Publisher's DOI)
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Full text (open access)
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