Title
Empowering gamma delta T cells with antitumor immunity by dendritic cell-based immunotherapy Empowering gamma delta T cells with antitumor immunity by dendritic cell-based immunotherapy
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Subject
Human medicine
Source (journal)
Oncoimmunology
Volume/pages
4(2015) :8 , 9 p.
ISSN
2162-4011
2162-402X
2162-402X
Article Reference
e1021538
Carrier
E-only publicatie
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Gamma delta (γδ) T cells are the all-rounders of our immune-system with their major histocompatibility complex-unrestricted cytotoxicity, capacity to secrete immunosti-mulatory cytokines and ability to promote the generation of tumor antigen-specific CD8+ and CD4+ T cell responses. Dendritic cell (DC)-based vaccine therapy has the prospective to harness these unique features of the γδ T cells in the fight against cancer. In this review, we will discuss our current knowledge on DC-mediated γδ T cell activation and related opportunities for tumor immunologists.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/b38bfa/127685.pdf
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