Title
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Hurdles in therapy with regulatory T cells
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Author
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Abstract
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Improper activation of the immune system contributes to a variety of clinical conditions, including autoimmune and allergic diseases as well as solid organ and bone marrow transplantation. One approach to counteract this activation is through adoptive therapy with regulatory T cells (T-regs). Efforts to manufacture these cells have led to good maunfacturing practice-compliant protocols, and T-reg products are entering early clinical trials. Here, we report the stance of the European Union Cooperation in Science and Technology Action BM1305, "Action to Focus and Accelerate Cell-based Tolerance-inducing Therapies-A FACTT," which identifies hurdles hindering T-reg clinical applications in Europe and provides possible solutions. |
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Language
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English
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Source (journal)
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Science translational medicine. - -
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Publication
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2015
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ISSN
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1946-6234
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DOI
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10.1126/SCITRANSLMED.AAA7721
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Volume/pages
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7
:304
(2015)
, 10 p.
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Article Reference
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304ps18
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ISI
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000360943900002
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Medium
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E-only publicatie
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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