Publication
Title
On the measurement of circulating antioxidant capacity and the nightmare of uric acid
Author
Abstract
P>1. In recent years, evolutionary ecologists have become increasingly interested in antioxidants and oxidative stress. Information on redox systems can provide new insights into our understanding of life-history variation and animal responses to environmental stressors. 2. A common approach of ecological studies to the study of antioxidant capacity of animals has been measurement of the total antioxidant capacity of serum or plasma. Some of these studies have suggested that most of the antioxidant capacity measured in plasma is made up of uric acid and, therefore, estimates of antioxidant capacity should be corrected for the concentration of uric acid. 3. Here, I show that (i) the correlation between plasma concentration of uric acid and plasma antioxidant capacity is method dependent and (ii) different assays for the quantification of circulating antioxidant capacity can provide information on different components of the antioxidant machinery. 4. To determine whether measurements of antioxidant capacity need to be corrected for the uric acid concentration in the sample, it is therefore important to take into account the biochemical properties of the assay used.
Language
English
Source (journal)
Methods in Ecology and Evolution
Publication
2011
ISSN
2041-210X
Volume/pages
2:3(2011), p. 321-325
ISI
000291228700012
Full text (Publishers DOI)
Full text (publishers version - intranet only)
UAntwerpen
Faculty/Department
Publication type
Subject
External links
Web of Science
Record
Identification
Creation 06.10.2015
Last edited 10.05.2017