Title
Biochemical integration of blood redox state in captive zebra finches (**Taeniopygia guttata**) Biochemical integration of blood redox state in captive zebra finches (**Taeniopygia guttata**)
Author
Faculty/Department
Faculty of Sciences. Biology
Publication type
article
Publication
London ,
Subject
Biology
Human medicine
Source (journal)
The journal of experimental biology. - London
Volume/pages
214(2011) :7 , p. 1148-1152
ISSN
0022-0949
ISI
000288155200021
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
Integration is a property of biological systems that refers to the extent to which their components are correlated through functional, structural, developmental or evolutionary interdependency. This study examined patterns of functional integration among different molecular components of the blood redox system (both plasma and red blood cells) in zebra finches (Taeniopygia guttata). Our results show a two cluster organization of the six measured variables: one cluster includes glutathione peroxidase in both red blood cells and plasma, thiol concentration in red blood cells and plasma hydroperoxides; the other cluster comprises a measure of the non-enzymatic antioxidant capacity in red blood cells and plasma. The interaction network amongst these variables shows (i) a strong positive connectivity among hydroperoxides, glutathione peroxidase and thiols, and (ii) negative connectivity between non-enzymatic and enzymatic antioxidants. Overall, our results also suggest strong and significant integration between the oxidative state of red blood cells and plasma.
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