Title
Effects of T-cell-mediated immune response on avian oxidative stress Effects of T-cell-mediated immune response on avian oxidative stress
Author
Faculty/Department
Faculty of Sciences. Biology
Publication type
article
Publication
London ,
Subject
Biology
Source (journal)
Comparative biochemistry and physiology : A : molecular & integrative physiology. - London
Volume/pages
145(2006) :1 , p. 137-142
ISSN
1095-6433
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
We evaluated the oxidative cost paid by birds when coping with an immune challenge. We used the phytohaemagglutinin skin test (PHA) to assess the effects of the T-cell-mediated immune response on the concentration of reactive oxygen metabolites (ROMs), total antioxidant barrier (OXY) and total serum carotenoid concentration in wild nestlings of the Eurasian kestrel (Falco tinnunculus). Immunostimulation caused increased levels of ROMs, decreased OXY and increased circulating levels of carotenoids. These results suggest that an immune challenge can increase avian oxidative stress, and that carotenoids were remobilised from other tissues likely because their circulating levels were not sufficiently high to sustain an effective immune response.
E-info
https://repository.uantwerpen.be/docman/iruaauth/0d2e17/4ca780aca3e.pdf