Title
Does immune response cause oxidative stress in birds? A meta-analysis Does immune response cause oxidative stress in birds? A meta-analysis
Author
Faculty/Department
Faculty of Sciences. Biology
Publication type
article
Publication
London ,
Subject
Biology
Source (journal)
Comparative biochemistry and physiology : A : molecular & integrative physiology. - London
Volume/pages
153(2009) :3 , p. 339-344
ISSN
1095-6433
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
In recent years ecological research has focused on the relevance of antioxidants and oxidative stress in the evolution of life-history strategies and physiological trade-off in birds. Some studies sought to evaluate whether a consequence of immune response is oxidative stress. In a meta-analysis of 16 studies of ten species of birds including 49 estimates of effect size from experimental studies, we show that induction of an immune response in a diverse group of bird species may determine oxidative stress (variance explained: 4.1%), but, most notably, may determine changes in oxidative stress markers (variance explained: 15.0%). These conclusions were robust to control for sampling effort and publication bias. Finally, this finding suggests that (1) oxidative stress may be a physiological cost associated with the immune response and (2) an important role of antioxidants in birds is to control the potentially negative effects of such oxidative stress to prevent immuno-pathological damage to host tissues.
E-info
https://repository.uantwerpen.be/docman/iruaauth/3c6983/be1671df7ac.pdf