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Title
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Does immune response cause oxidative stress in birds? A meta-analysis
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Author
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Abstract
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| In recent years ecological research has focused on the relevance of antioxidants and oxidative stress in the evolution of life-history strategies and physiological trade-off in birds. Some studies sought to evaluate whether a consequence of immune response is oxidative stress. In a meta-analysis of 16 studies of ten species of birds including 49 estimates of effect size from experimental studies, we show that induction of an immune response in a diverse group of bird species may determine oxidative stress (variance explained: 4.1%), but, most notably, may determine changes in oxidative stress markers (variance explained: 15.0%). These conclusions were robust to control for sampling effort and publication bias. Finally, this finding suggests that (1) oxidative stress may be a physiological cost associated with the immune response and (2) an important role of antioxidants in birds is to control the potentially negative effects of such oxidative stress to prevent immuno-pathological damage to host tissues. |
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Language
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English
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Source (journal)
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Comparative biochemistry and physiology : A : molecular & integrative physiology. - London
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Publication
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London
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2009
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ISSN
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1095-6433
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DOI
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10.1016/J.CBPA.2009.03.010
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Volume/pages
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153
:3
(2009)
, p. 339-344
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ISI
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000266686700015
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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