Title
Diffusion kurtosis imaging : a possible MRI biomarker for AD diagnosis? Diffusion kurtosis imaging : a possible MRI biomarker for AD diagnosis?
Author
Faculty/Department
Faculty of Sciences. Physics
Faculty of Medicine and Health Sciences
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Publication type
article
Publication
Subject
Physics
Biology
Human medicine
Source (journal)
Journal of Alzheimer's disease
Volume/pages
48(2015) :4 , p. 937-948
ISSN
1387-2877
ISI
000363867300006
Carrier
E
Target language
Dutch (dut)
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
The purpose of this explorative study was to investigate whether diffusion tensor imaging (DTI) and diffusion kurtosis imaging (DKI) parameter changes are reliable measures of white matter integrity changes in Alzheimers disease (AD) patients using a whole brain voxel-based analysis (VBA). Therefore, age- and gender-matched patients with mild cognitive impairment (MCI) due to AD (n=18), dementia due to AD (n=19), and age-matched cognitively healthy controls (n=14) were prospectively included. The magnetic resonance imaging protocol included routine structural brain imaging and DKI. Datasets were transformed to a population-specific atlas space. Groups were compared using VBA. Differences in diffusion and mean kurtosis measures between MCI and AD patients and controls were shown, and were mainly found in the splenium of the corpus callosum and the corona radiata. Hence, DTI and DKI parameter changes are suggestive of white matter changes in AD.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/9cde24/128058.pdf
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