Publication
Title
Diffusion kurtosis imaging : a possible MRI biomarker for AD diagnosis?
Author
Abstract
The purpose of this explorative study was to investigate whether diffusion tensor imaging (DTI) and diffusion kurtosis imaging (DKI) parameter changes are reliable measures of white matter integrity changes in Alzheimers disease (AD) patients using a whole brain voxel-based analysis (VBA). Therefore, age- and gender-matched patients with mild cognitive impairment (MCI) due to AD (n=18), dementia due to AD (n=19), and age-matched cognitively healthy controls (n=14) were prospectively included. The magnetic resonance imaging protocol included routine structural brain imaging and DKI. Datasets were transformed to a population-specific atlas space. Groups were compared using VBA. Differences in diffusion and mean kurtosis measures between MCI and AD patients and controls were shown, and were mainly found in the splenium of the corpus callosum and the corona radiata. Hence, DTI and DKI parameter changes are suggestive of white matter changes in AD.
Language
Dutch, English
Source (journal)
Journal of Alzheimer's disease
Publication
2015
ISSN
1387-2877
Volume/pages
48:4(2015), p. 937-948
ISI
000363867300006
Full text (Publishers DOI)
Full text (open access)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 12.10.2015
Last edited 23.05.2017
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